Long Noncoding RNA IGFBP7-AS1 Promotes Odontogenesis of Stem Cells from Human Exfoliated Deciduous Teeth via the p38 MAPK Pathway

Figure 6

IGFBP7-AS1 regulates the odontogenic differentiation of SHED via the p38 MAPK pathway. (a) Western blot detected the expression of p-p38 and p38 in the si-NC and si-IGFBP7-AS1 groups. The ratio of p-p38 and p38 was calculated. (b) Western blot detected the expression of p-p38 and p38 in the NC and IGFBP7-AS1 groups. (c) Western blot detected the expression of p-p38 and p38 in the NC and IGFBP7-AS1 groups after adding the inhibitor of the p38 MAPK signaling pathway. The ratio of p-p38 and p38 was calculated. (d) Images of ALP staining and ARS staining of IGFBP7-AS1 overexpressed SHED odontogenic differentiation with or without SB203580. (e) qRT-PCR detected odontogenic differentiation-related markers: ALP, DSPP, and DMP1 of IGFBP7-AS1 overexpressed SHED odontogenic differentiation with or without SB203580. Data were expressed as the (SD) of three experiments per group, , , and .

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