MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

<div>EVs-L-PGDS increased L-PGDS and reduced stem cell marker expression and inhibited STAT3 phosphorylation in the gastric cancer cell SGC-7901. (a) Confocal microscopy for the location of EVs in SGC-7901 cells (×600). (b) Western blot for the expression level of L-PGDS in SGC-7901 cells. (c) Quantitative analyses of protein expression of L-PGDS. (d) Western blot for the expression level of <i>Oct4</i>, <i>Nanog</i>, and <i>Sox2</i> in SGC-7901 cells. (e) Quantitative analyses of protein expression of <i>Oct4</i>, <i>Nanog</i>, and <i>Sox2</i>. (f) Western blot for the expression of p-STAT3 (Thy705), t-STAT3, and GAPDH in SGC-7901 cells. 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Stem Cells International

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Figure 3

Figure 3: MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation 

Figure 3 | MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation 