Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy

<div>Schematic diagram of antiaging effect of metformin in hBMSCs. Metformin exerts antiaging function within the low concentration range by enhancing autophagic flux. hBMSCs: human bone marrow-derived mesenchymal stem cells; ROS: reactive oxygen species; MMP: mitochondrial membrane potential; AMPK: 5<svg height="7.86364pt" id="M70" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>AMP-activated protein kinase.</div>

Stem Cells International

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Figure 6

Figure 6: Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy 