Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice

Figure 5

Cotransplantation of MSCs with BM reduced the lesion size in mice. (a) Schematic diagram showing timeline for BMT performed with or without MSCs into irradiated mice (N = 8 per group). Endometriosis was induced on Day 30 after BMT and tissue was collected after 60 days. (b) Representative images of H&E stained endometriotic lesions from BM and MSC + BM groups (N = 8). Scale bar: 300 µm. (c) Photograph showing reduced lesion size in MSC + BM group compared to BM transplanted group. Lesion volume was assessed on Day 60 after surgery. Data (N = 8) are expressed as means ± SEM. .

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