Bone Marrow-Derived Mesenchymal Stem Cells and γ-Secretase Inhibitor Treatments Suppress Amyloid-β25–35-Induced Cognitive Impairment in Rat Dams and Cortical Degeneration in Offspring

Figure 14

Effect of treatment with MSCs and GSI-953 on the gene expression of (a) BDNF, (b) cleaved caspase-3, (c) TGF-β, (d) NF-κB, and (e) TNFR in the newborn cortex of Aβ25–35-induced Alzheimer’s disease dams evaluated via qRT-PCR. Data were analyzed via two-way ANOVA followed by Tukey’s multiple comparison test. Data are expressed as . , , and vs. the saline-injected group. ^#, ^##, and ^### vs. the AD group. ns: nonsignificant ().

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