[Retracted] miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer

Figure 6

SOX11 was a target of miR-4780 and aggravated EMT and angiogenesis of COLO205. (a) The expression of SOX11 in COAD from TCGA. (b and c) Overall survival and disease-free survival of SOX11 in COAD from TCGA. (d) Structure of human SOX11 gene and location of hsa-miR-4780. (e) Relative luciferase activity of different groups. (f) Expression of miR-4780. (g and h) Protein expression of SOX11. (i–l) The expression of EMT-associated proteins, E-cadherin, N-cadherin, and vimentin in COLO205 were measured via western blot. (m–o) The expression of angiogenesis-associated proteins, CD34, and VEGF in HUVECs were measured via western blot. (p) CCK8 assay for cellular viability of HUVECs. (q–s) Wound healing assay for cell migration of HUVECs. (n, p; ) and tube formation assay (o, q; ) ; ; .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)

(n)

(o)

(p)

(q)

(r)

(s)