A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories

Figure 1

Single-cell atlas of GBM samples. (a) UMAP plot of GBM transcriptomes, color-coded for 5 phenotypes identified by graph-based clustering. (b) UMAP plot color-coded for each GBM sample. (c) UMAP plot of GBM tumor cell cluster color-coded for 7 phenotypes. (d) UMAP plot of microglial cells color-coded for 5 phenotypes. (e) Reproducible cell subset distributions across samples. Fractions of cells in each cluster derived from all samples are shown. (f) The heatmap of the expression of subset-specific markers across cell subsets.