Stem Cells International

Research Article

AT7867 Inhibits the Growth of Colorectal Cancer Stem-Like Cells and Stemness by Regulating the Stem Cell Maintenance Factor Ascl2 and Akt Signaling

Table 2

Pathways related to CSCs in Reactome and GO databases.


Stem cell function-related pathways	Pathway ID	Gene count

GO: somatic stem cell population maintenance	GO:0035019	72
GO: negative regulation of stem cell differentiation	GO:2000737	20
GO: stem cell proliferation	GO:0072089	118
GO: hematopoietic stem cell differentiation	GO:0060218	79
GO: negative regulation of stem cell proliferation	GO:2000647	16
GO: stem cell division	GO:0017145	41
GO: hematopoietic stem cell proliferation	GO:0071425	23
GO: positive regulation of stem cell differentiation	GO:2000738	20
GO: regulation of stem cell population maintenance	GO:2000036	28
GO: neuronal stem cell population maintenance	GO:0097150	22
GO: regulation of stem cell proliferation	GO:0072091	67
GO: somatic stem cell division	GO:0048103	24
GO: stem cell differentiation	GO:0048863	248
GO: positive regulation of stem cell proliferation	GO:2000648	40
GO: regulation of stem cell differentiation	GO:2000736	112
GO: hematopoietic stem cell migration	GO:0035701	6
GO: stem cell fate commitment	GO:0048865	9
GO: mesenchymal stem cell maintenance involved in nephron morphogenesis	GO:0072038	6
GO: mesenchymal stem cell differentiation	GO:0072497	8
GO: mesenchymal stem cell proliferation	GO:0097168	5
GO: asymmetric stem cell division	GO:0098722	10
GO: regulation of hematopoietic stem cell proliferation	GO:1902033	9
GO: positive regulation of hematopoietic stem cell proliferation	GO:1902035	5
GO: negative regulation of stem cell population maintenance	GO:1902455	8
GO: positive regulation of stem cell population maintenance	GO:1902459	8
GO: regulation of somatic stem cell population maintenance	GO:1904672	7
GO: negative regulation of somatic stem cell population maintenance	GO:1904673	5
GO: regulation of stem cell division	GO:2000035	10
GO: regulation of mesenchymal stem cell differentiation	GO:2000739	6
Reactome transcriptional regulation of pluripotent stem cells	R-HSA-452723	31

Note: human CSC-related pathways were downloaded from the Molecular Signature Database v7.0 (MSigDB), and 456 genes related to CSCs were sorted from the 30 lipid metabolism pathways as Liang et al. described previously [21].