Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1α Branch of the Endoplasmic Reticulum Stress Response

Figure 7

MSCs alleviated BLM-induced pulmonary injury in mice. (a) Diagram of the groups for the in vivo experiments. (b) Body weight curves of mice in the different groups (n = 5, Student’s t test). (c) The overall appearances of the left and right lungs of mice from the anterior view. (d–f) Serum levels of TNF-α, IL-1β and IL-6 were measured after 4 weeks (n = 5, Student’s t test). (g) Representative HE-stained images of mouse lung tissues. Scale bar, 250 μm (100x), 50 μm (400x). (h–i) The percentage of alveolar space and alveolar number were analyzed in ImageJ (n = 10, one-way ANOVA with the Bonferroni post hoc test). The data are shown as the means ± SEMs (, vs. the control group; ^# vs. the BLM group).

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