Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1α Branch of the Endoplasmic Reticulum Stress Response

Figure 8

MSCs ameliorated BLM-induced pulmonary fibrosis in mice. (a) HYP content in lung tissue was assessed (n = 5, one-way ANOVA with the Bonferroni post hoc test). (b) Representative Masson’s trichrome-stained images of the lung tissues of mice. Scale bar, 250 μm (100x), 50 μm (400x). (c) The fibrosis area was analyzed in ImageJ (n = 10, one-way ANOVA with the Bonferroni post hoc test). (d) The serum levels of TGF-β1 were measured after 4 weeks (n = 5, Student’s t test). The data are shown as the means ± SEMs (, vs. the control group; ^# vs. the BLM group).

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