Review Article

Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm

Table 4

11 stem cell therapeutic drugs approved for marketing worldwide.

CountryTrade nameCell typeIndicationApproved time

The United StatesProchymalBone marrow mesenchymal stem cellsGraft versus host disease (GVHD), Crohn’s disease2010.05

The European UnionStempeucelBone marrow mesenchymal stem cellsThromboangiitis obliterans2015.06
AlofiselAdipose-derived mesenchymal stem cellsCrohn’s disease with complex perianal fistula2018.03

South KoreaCell gramBone marrow mesenchymal stem cellsAcute myocardial infarction2011.07
CartistemUmbilical cord blood mesenchymal stem cellsDegenerative arthritis and knee cartilage injury2012.01
CuepistemAdipose-derived mesenchymal stem cellsComplex Crohn’s disease complicated with anal fistula2012.01
NeuroNATA-RBone marrow mesenchymal stem cellsAmyotrophic lateral sclerosis, motor neuron disease2014.07

CanadaProchymalBone marrow mesenchymal stem cellsGraft versus host disease (GVHD) in children2012.05

AustraliaMPCAutologous mesenchymal precursor cellsRepair of damaged bone tissue2010.07

JapanTemcellBone marrow mesenchymal stem cellsGraft versus host disease (GVHD)2016.02
RNL-AstrostemAdipose-derived mesenchymal stem cellsAlzheimer’s disease2018.04
StemiracBone marrow mesenchymal stem cellsSpinal cord injury2018.12

IndiaStempeucelBone marrow mesenchymal stem cellsSevere lower limb ischemia caused by Burger’s disease2017