Human Mesenchymal Stem Cells-Derived Exosome Mimetic Vesicles Regulation of the MAPK Pathway and ROS Levels Inhibits Glucocorticoid-Induced Apoptosis in Osteoblasts

Figure 1

DEX induced apoptosis in MC3T3-E1 cells. (a) Cell viability of MC3T3-E1 after intervention with different concentrations of dexamethasone. (b and c) Level of apoptosis in MC3T3-E1 cells after DEX intervention by flow cytometry. (d and e) Expression of apoptosis-related proteins Bax and Bcl 2 after DEX intervention. (f) ROS generation level of MC3T3-E1 cells after DEX intervention (scale bar: 100 μm). (g and h) HO-1 and Nrf 2 expression after DEX intervention by western blot. , , , and compared wtih control group.

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