Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner In Vitro

Figure 1

Tumor growth in a human SK-MEL-28 tumor-bearing xenograft mouse model. Calculated tumor volume over 21 days in the SK-MEL-28 tumor xenograft NOD SCID mouse model treated with three lines of HUCPVC (FTM 1, FTM 2, and term) or HBSS (control), n = 11–12 per group. Three independent experiments were performed and animals were randomized on Day 0. Measurements were done by a blinded observer. (a) Time course showing FTM 2 and term HUCPVC-treated animals have significantly reduced tumor volume when compared to controls (and FTM 1) at Day 7, 14, and 21. FTM 1-treated animal tumors do not significantly differ from controls (and FTM 2 and Term 1 do not significantly differ from each other). Error bars represent SEM. (b) Weekly tumor volume plotted by group, showing statistically significant differences between Day 0 and other timepoints for each study group. (c) Images of representative tumors after dissection at 3 weeks. (d) Tumor weights after dissection at 3 weeks (n = 4 per group). Error bars represent SEM , ; , , , .

(a)

(b)

(c)

(d)