Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy

<div>UC-MSCs inhibit renal pyroptosis through the NLRP3/Caspase1 signaling pathway <i>in vivo</i>. (a–c) Representative graphs of kidney sections with immunohistochemistry staining for NLRP3, Caspase1, and IL-1<i>β</i>. Scale bar, 50 <i>μ</i>m. (d, e) The protein levels of NLRP3, ASC, Caspase1, GSDMD, and IL-1<i>β</i> were measured by western blot in the control, DN, and DN+UC-MSC groups. (f) RT-PCR analysis of NLRP3, ASC, Caspase1, IL-1<i>β</i>, and IL-18 mRNA expressions in the control, DN, and DN+UC-MSC groups. 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Stem Cells International

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Figure 4

Figure 4: Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy 

Figure 4 | Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy 