Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways

Figure 6

Effects of AZIL and AD-MSCs on hepatic JNK1/2, ERK1/2, p38, Bax, Bcl-2, and cleaved caspase-3 proteins expression of CISP-intoxicated rats. Representative western blot results of the assessed proteins in the liver of the investigated groups (a). Expressions of p-JNK1/2/total JNK1/2, p-ERK1/2/total ERK1/2, p-P38/total P38, Bax, Bcl-2, and cleaved caspase-3, respectively, were displayed densitometrically, utilizing bands in (a) after normalization to the internal CONT β-actin, as fold change relative to that of CONT group (b–g). Data are represented as mean ± SEM. Followed by Tukey–Kramer multiple comparisons test, analyses were carried out utilizing one-way ANOVA, where: , in comparison with CONT group. ^## and ^###, in comparison with the CISP group. ^{^^^}, in comparison with CISP + AZIL.L group. ⁺⁺ and ⁺⁺⁺, in comparison with CISP + AZIL.H group. ^$$$, in comparison with CISP + AD-MSCs group.

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