Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways

Figure 8

Effects of AZIL and AD-MSCs on hepatic histopathology examinations (a). Representative micrographs of liver sections from CONT as well as AZIL groups showing normal hepatic architecture. The hepatocytes radiated from the central vein (c.v) and separated by blood sinusoids (green arrows). Hepatocytes showing vesicular nuclei (black arrows). CISP group show dilated central vein (c.v) and dilated sinusoids (green arrow). Notice the apoptotic cell (black arrow) and inflammatory cell infiltration (circle). CISP + AZIL.L and CISP + AZIL.H groups showing dilated central vein (c.v) and dilated sinusoids (green arrow). Notice the apoptotic cell (black arrow) and inflammatory cell infiltration (circle). CISP + AD-MSCs group showing dilated blood sinusoids (green arrow) with little apoptotic cell (black arrow). CISP + AZIL.L + AD-MSCs group showing dilated blood sinusoids (green arrow) with little apoptotic cell (black arrow). CISP + AZIL.H + AD-MSCs group showing little apoptotic cells (black arrow) with few vacuolations (v). Liver cells in the CISP + VITA C group appeared with cytoplasmic vacuolations (v). Darkly stained cells (yellow arrow) can be seen (H&E × 400). The average count of inflammatory cell infiltration (b) and the average count of apoptotic cells (c). Data are represented as mean ± SEM (n = 6). Followed by the Tukey–Kramer multiple comparisons test, analyses were carried out utilizing one-way ANOVA, where: , in comparison with CONT group. ^###, in comparison with the CISP group. ^{^^^}, in comparison with CISP + AZIL.L group. ⁺⁺⁺, in comparison with CISP + AZIL.H group. ^$$$, in comparison with CISP + AD-MSCs group.

(a)

(b)

(c)