Research Article

BMSC-Derived Exosomes Alleviate Sepsis-Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction

Figure 5

BMSC-exos alleviated sepsis-induced ARDS via activating the Nrf2 pathway in vivo. The randomly assigned mice were administered ML385 (30 mg/kg) intraperitoneally 2 hours before CLP surgery and injected intratracheally with BMSC-exos (300 μg/mouse) 1 hour before CLP surgery. (a) Survival rate of mice. (b) H&E staining of lung tissue sections. (c) Total protein concentrations in BALF. (d) Wet/dry ratio of lung tissue. (e) Levels of the IL-6 in BALF. (f) Immunohistochemistry of HMGB1 expression in lung tissue sections. Data are presented as , per group. NS: nonsignificance; vs. the control group; ### vs. the LPS group or CLP group.
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