BMSC-Derived Exosomes Alleviate Sepsis-Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction

Figure 6

Proposed mechanism for the function of BMSC-exos in alleviating sepsis-associated acute respiratory distress syndrome by activating the Nrf2 pathway to reverse mitochondrial dysfunction. Mitochondrial dysfunction, including depression of mitochondrial biogenesis and excessive mitochondrial fission, might contribute to sepsis-induced AECII apoptosis. BMSC-exos enhanced the expression of Nrf2, subsequently promoting mitochondrial biogenesis and inhibiting mitochondrial fission in AECIIs, alleviating AECII apoptosis and ARDS. Arrows indicate positive regulation, T-bars indicate negative regulation, and cross shows the blocking effect.