Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs)

<div>Effects of ginsenoside Rg1 on the cell cycle phase distribution and proliferation of hAD-MSCs after blocking the PI3K/AKT signaling. (a, b) The cell cycle phase distribution of hAD-MSCs was detected (a) and compared (b) by flow cytometry after pretreatment of hAD-MSCs with or without LY294002 for 1 h followed by the treatment with or without Rg1 in the control, Rg1, Rg1+LY294002, and LY294002 groups (<i>n</i> = 3). (c–e) The proliferation of hAD-MSCs was detected and compared by CCK-8 (c) and EdU incorporation (d, e) assays after pretreatment of hAD-MSCs with or without LY294002 for 1 h followed by the treatment with or without Rg1 in the control, Rg1, Rg1+LY294002, and LY294002 groups (100x) (<i>n</i> = 6). A representative sample of three independent experiments is shown. 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Stem Cells International

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Figure 4

Figure 4: Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs) 