Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation

Figure 8

Lama2 and Samsn1 partially reversed the decrease of NSCs differentiation into neurons caused by Brn4 knockdown. (a–c) Representative immunoblots of Tuj1, GFAP, and β-actin in the primary hippocampal NSCs after induced differentiation for 7 days (a) and quantification of Tuj1 and GFAP protein levels normalized to β-actin (b, c). (d, e) Quantification of MAP2 and S100b mRNA levels normalized to β-actin after the NSCs induced differentiation for 7 days. (f, g) Quantification of Lama2 and Samsn1 mRNA levels normalized to β-actin. Error bars represent the . . , , and vs. Ctrl; ^# and ^##vs. Brn4-shRNA.

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