Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung

Figure 1

CD11b⁺ myeloid cells infiltrated into the lungs after IV administration of hUC-MSCs. (a) Representative maximum intensity projection confocal microscopy images showed CD11b⁺ cells (white) were present in the lungs of animals that received hUC-MSCs, but were not present in control animals that received saline. CD11b⁺ cells clustered around the hUC-MSCs (red) in the lungs at 2 and 24 hr after cell injection (yellow arrows). Scale bar = 30 µm. (b) Immunofluorescence quantification of CD11b⁺ cells. Kruskal–Wallis test with multiple comparisons. n = 3, ; . The number of fields of view counted per condition was 27.

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