Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neuroinflammation, and Apoptosis

Figure 6

Effects of WJMSC-CM and insulin on oxidative stress markers in hippocampus of diabetic rats. According to one-way ANOVA (post hoc: Tukey) analysis, administration of WJMSC-CM improved the hippocampus levels of MDA and GSH, as well as the activity of GPx in diabetic rats. Insulin restores all oxidative stress parameters to normal value. The values are presented as (). Significant differences versus the control (, , ) and diabetes rats (^#, ^##, ^###, ^####). Con: control; Dia: diabetes; Dia + CM: WJMSC-CM-treated diabetic group; Dia + INS: insulin-treated diabetic group; Dia + DMEM: DMEM-treated diabetic group.

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