Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics

Figure 1

Tumor initiation cells known for their ability to initiate tumor formation due to mutations, serve as the “seeds” of malignancy. These cells allow cancer to take root and propagate. Tumor initiation cells are often associated with the process of epithelial–mesenchymal transition (EMT), a critical event in cancer progression. This figure is adapted from the study of Zhou et al. [108].