The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues

<div>Comparison between fibrotic multicellular liver microtissues (MLMs) on Days 4 and 8. (a) Representative fluorescence images (scale bars: 50 <i>μ</i>m), and (b) relative intensity of collagen I in MLMs supplemented with free fatty acids (FFAs). (c) Quantification of interlukine-6 (IL-6) secretion. (d and f) Accumulated lipid droplets. 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240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,57.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,64.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>).</span> (h) Flow cytometry analysis of Annexin V assay in health and FFA groups (scale bars: D and E 100 <i>μ</i>m). Abbreviation: MLMs, multicellular liver microtissues; FFAs, free fatty acids; IL-6, interlukine-6.</div>

Stem Cells International

fig2

Figure 2

Figure 2: The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues 