Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation

Figure 4

Chromosomal aberration assessment in the control group of MSCs. The experiment was conducted with three independent replications using a standard culture medium: (a) MN frequency (mean ± SD) per 1,000 binucleated cells was evaluated at 2, 10, and 15 days after the fourth passage. Mean comparison conducted via one-way ANOVA test (ns, not significant); (b) cumulative diagram of the mean nuclear alterations, including MNs, NPBs, and NBUDs, in binucleated cells; (c) mean nuclear alterations in mesenchymal stem cells over the time.

(a)

(b)

(c)