Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate S100-Induced Autoimmune Hepatitis via Modulating Th1 and Th17 Cell Responses in Mice

Figure 2

Human UC-MSCs alleviate S100-induced experimental AIH in mice. (a) Intervention and treatment schedule to establish the AIH model, mice were sacrificed on day 35 after the first immunization, (b) representative general morphology of livers and spleens from the different groups are shown on day 35 (n = 8), (c and d) changes in spleen and liver indexes on day 35 (n = 8) ( , ), (e–g) changes in blood serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and globulin (GLB) levels in mice (n = 8) ( , ), and (h and i) representative images of liver tissues in each group (hematoxylin and eosin staining) and Knodell-HAI scores of mouse liver (n = 8) ( ). HAI, histological activity index.

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