Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate S100-Induced Autoimmune Hepatitis via Modulating Th1 and Th17 Cell Responses in Mice

Figure 4

RNA-Seq analysis of gene expression and signaling pathway changes in AIH liver tissue. (a) Cluster analysis based on sample correlation coefficient (samples with higher correlation coefficients have higher similarity and closer clustering relationships), (b) heatmap clustering of all DEGs (horizontal is the sample, vertical is the gene), (c) volcanic map of DEGs between control group and AIH model group, (d) volcanic map of DEGs between model group and UC-MSC-treated group (the horizontal axis in the figure represents the multiple changes in expression level (log value is taken as the base of 2), while the vertical axis represents the statistical significance of the differences in expression level changes (log value is taken as the base of 10)), (e and f) GO analysis of up-regulated and down-regulated genes between control and AIH model group, (g) heatmap of DEGs among the three groups, and (h) analysis of differential immune cells among the three groups by CIBERSORTx.

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