HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway

Figure 8

Schematic model of the proposed mechanism of erroneous differentiation of TSPCs under high glucose. Under high glucose conditions, increased HMGB1 activates the RAGE/β-catenin signaling pathway, leading to enhanced osteogenic differentiation of TSPCs and decreased tenogenic differentiation, contributing to the pathogenesis of diabetic tendinopathy.