The Neural Progenitor Cell-Associated Transcription Factor FoxG1 Regulates Cardiac Epicardial Cell Proliferation

Table 1

Top upregulated and downregulated gene transcripts in CD104⁺ epicardial cells from running-exercised mice compared with genes expressed in CD104⁺ cells from nonrunners.

Up in running			Down in running
Gene name	Fold change	Adjusted p-value	Gene name	Fold change	Adjusted p-value
Snord116	7.08	0.044	Igk-V28	−3.84	0.037
Mir101c	6.17	0.020	Zfp125	−3.13	0.008
Gm9602	4.91	0.034	Xlr3b	−3.12	0.440
Srsy	4.74	0.010	Gm13034	−3.04	0.031
Ssty2	4.22	0.041	Mirlet7f-1	−3.02	0.026
MGC107098	3.70	0.038	Snord61	−2.94	0.023
Gm2046	3.46	0.015	Omd	−2.64	0.008
Ssty1	3.05	0.001	Zfp932	−2.60	0.049
Sly	3.12	0.047	Pyhin1	−2.47	0.036

Cells were acutely isolated from hearts after 1 week of running exercise (ad libitum) or from hearts of aged-matched, nonrunning littermate controls. Our expression profiling analysis of epicardial cells identified 4,112 transcripts that were differentially expressed between cells of runners vs. nonrunners. Of these, 2,300 total transcripts were increased in runners and 1,812 total transcripts were decreased in runners ().