Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects

Figure 3

(a) Correspondence analysis (CA) plot of depleted serum samples from healthy subjects using the expression dataset of 5 identified proteins/peptides (PPs) that were significantly differentially expressed ( < 0.05-ANOVA, MFC ≥1.5- minimum fold change) between men and women. The expression profiles of the identified PPs clearly differentiate women from men using correspondence analysis. (The image was generated using J-express pro V1.1 software program (java.sun.com)). (b) Unsupervised hierarchical cluster analysis of the expression profiles of depleted serum samples using 5 proteins that differ significantly ( < 0.05, analysis of variance; maximum fold change ≥1.5) between men (red) and women (blue). The dendrogram was generated using the Bray–Curtis correlation distance metric and an average linkage clustering method from the J-express pro V1.1 software program (java.sun.com). Note. One PP (IGHG1) was upregulated in both nondepleted (Figure 2) and depleted sera.

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