The Trends and Risk Factors of AIDS-Defining Cancers and Non-AIDS-Defining Cancers in Adults Living with and without HIV: A Narrative Review

Mathoma, Anikie; Sartorius, Benn; Mahomed, Saajida

doi:https://doi.org/10.1155/2024/7588928

Journal of Cancer Epidemiology

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Abstract Introduction Methods Results Discussion Conclusion Data Availability Disclosure Conflicts of Interest Acknowledgments References Copyright Related Articles

Review Article | Open Access

Volume 2024 | Article ID 7588928 | https://doi.org/10.1155/2024/7588928

The Trends and Risk Factors of AIDS-Defining Cancers and Non-AIDS-Defining Cancers in Adults Living with and without HIV: A Narrative Review

Anikie Mathoma,^1,2Benn Sartorius,^1,3,4,5and Saajida Mahomed¹

Academic Editor: Eleanor Kane

Received17 Oct 2023

Revised23 Jan 2024

Accepted28 Feb 2024

Published21 Mar 2024

Abstract

Background. People living with HIV (PLHIV) are at a high-risk of developing AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs). This review is aimed at exploring available evidence regarding the trends of ADCs and NADCs and the associated risk factors among adult PLHIV. Methods. We conducted a comprehensive search of PubMed, Web of Science, and EBSCO host databases to identify articles published between 2010 and 2023 that reported incidence and mortality rates of cancer, including ADCs and NADCs among PLHIV. We compared trends and rates in PLHIV with HIV-negative adults and further assessed related risk factors. Results. A total of 1886 potentially eligible articles were screened, and of these, 36 were included in this study. More than 50% () of these were based in high-income countries. Seventeen studies reported a higher prevalence of NADCs compared to ADCs, with twelve of these conducted in high-income countries. Conversely, eight out of twelve studies reporting a higher prevalence of ADCs versus NADCs were from low-and-middle and upper-middle-income countries. Ten studies indicated a higher incidence of ADCs (6 studies) and NADCs (4 studies) among PLHIV compared to HIV-negative individuals. In contrast, only two studies observed an increase in NADCs among the HIV-negative population. In comparing mortality, seven out of nine studies showed elevated NADC-related deaths compared to ADCs. The main risk factors identified for any cancer, NADCs, and related mortality were advancing age, and longer duration of HIV infection, while lower CD4 cell counts (<200 cells/μl), was associated with both ADC and NADC occurrences. Conclusion. Chronic HIV infection combined with advancing age in PLHIV taking antiretroviral therapy appears to have contributed to increasing cancer burden, particularly the incidence of NADCs and associated mortality. These findings stress the importance of screening for high-risk cancers among PLHIV for early detection and treatment to ensure improved outcomes.

1. Introduction

According to the World Health Organization (WHO), the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic continues to be a public health threat with an estimated 38.4 million people living with the virus globally in 2021, and of these, nearly 70% (25.6 million) reside in the African region [1]. People living with HIV (PLHIV) have an elevated risk of developing many opportunistic infections and cancers, primarily due to HIV-related immunosuppression, which impairs the control of oncogenic viral infections [2, 3]. The WHO estimates that as of 2020, cancer was the leading cause of mortality worldwide accounting for almost 10 million deaths with lung cancer leading with 1.8 million deaths [4]. Stomach, breast, colon, esophagus, pancreas, lung, and prostate versus one virus-related cancer (liver cancer) were leading in the number of cancer-related deaths by the end of 2020 [5].

Cervical cancer, Kaposi sarcoma (KS), and non-Hodgkin lymphoma (NHL) are the most common cancers among PLHIV [6–11], and these are classically referred to as AIDS-defining cancers (ADCs) as they indicate clinically relevant immunosuppression [2]. The introduction and expansion of combined antiretroviral therapy (cART) in the past two decades has resulted in a decline in the incidence of these cancers in many countries especially the high-income countries (HICs) [12–16]. Cervical cancer, KS, and NHL all have an infectious etiology: KS is caused by human herpesvirus 8 (HHV-8) [17], cervical cancer is caused by human papilloma virus (HPV) [18], and NHL is linked to Epstein-Barr virus (EBV) [19]. The risk of these ADCs remains high in many low- and middle-income countries (LMICs) where there are significant HIV-infected populations who are not on treatment or who are on treatment but not virologically suppressed [20–23]. Data from recent studies conducted in the United States of America (USA), Europe, and Australia have shown continued declines in the rates of ADCs [24–27]. Nevertheless, when compared with the general population, a USA study noted that while there has been dramatic declines in the trends of ADCs over the years, the rates of KS, NHL, and cervical cancer in PLHIV remain elevated at approximately 800-fold, 10-fold, and 4-fold, respectively, when compared to their HIV-negative counterparts [24]. According to the International Agency for Research on Cancer (IARC), LMIC regions had the highest cancer-related mortality rates caused by ADCs worldwide in 2020. Cervical cancer, NHL, and KS accounted for the highest cancer-related deaths in Africa, with cervical cancer causing 10.8% of deaths, NHL causing 4.4%, and KS causing 1.8%. In Asia, cervical cancer accounted for 3.4% of deaths, while NHL caused 2.3% of deaths [5].

As stated above, the effectiveness of cART in reducing ADCs burden has been demonstrated; however, there has been emergence of other cancers like lung, nonmelanoma skin, hepatocellular cancer (HCC), anal, and oropharyngeal categorized as non-AIDS-defining cancers (NADCs), and these type of cancers seem to occur more frequently in PLHIV who have been on ART and virologically suppressed for a long period [14, 27–33]. While the carcinogenic or anticarcinogenic potential of cART in NADCs is yet to be established, effective cART is thought to be fueling the incidence of NADCs because of its ability to increase survival and subsequently lead to prolonged life and time with HIV infection [29]. Non-AIDS-defining cancers can be classified into virus-related and virus unrelated. Examples of the virally mediated cancers are liver cancer caused by the hepatitis B and C viruses (HBV and HCV); vulva, penis, anal, oropharynx, and larynx cancers caused by HPV; and Hodgkin’s lymphoma caused by EBV. Lung, breast, stomach, and prostate cancers are some of the NADCs without a link to an underlying coinfectious agent [14, 34–36]. In addition to the infectious agents linked to ADCs and NADCs, demographic factors such as age; behavioral risk factors such as smoking, alcohol use, unhealthy diet, and physical inactivity; and environmental factors such as air pollution have also been identified as important drivers of cancer [4]. Most of these risk factors are attributed to a rise in NADCs such as liver, lung, and esophagus.

In response to the growing burden of cancer, the WHO has adopted the 2030 United Nations Agenda for Sustainable Development to reduce premature mortality from cancer by (i) monitoring the cancer burden through cancer registries and (ii) developing standards and tools to guide the planning and implementation of interventions for prevention, early diagnosis, screening, treatment, and palliative as well as survivorship care [4]. This narrative review is therefore aimed at (i) reviewing trends of ADCs and NADCs and the evolving risk factors as important indicators to show the progress made in reducing cancer incidence and mortality for individual cancer types and for cancer overall and (ii) identifying cancers that may be increasing in incidence. The data may likely improve our understanding of the trend assumptions, and underlying factors attributed to cancers that are increasing in incidence among PLHIV which may highlight a greater need for expanded access to HIV therapies, cancer prevention, screening, and treatment. Additionally, the data may suggest the need to assess the applicability of the current screening guidelines for PLHIV.

2. Methods

2.1. Search Strategy

Online databases including PubMed, Web of Science, and EBSCO host were searched for peer-reviewed research articles published on cancer trends and associated risk factors in English regardless of study setting or geographical area. The search was restricted to studies published from January 1, 2010, to December 31, 2023, to better understand the cancer trends in the second decade of ART roll-out. This period has been characterized by an increase in access to ART and the introduction of universal ART by the WHO in 2016 [37]. The following keywords were used on the search databases: cancer, cancer trends, HIV, AIDS-defining cancers, non-AIDS-defining cancers, incidence, prevalence, mortality, and risk-factors. Medical Subject Heading (MeSH) terms were used to search for the cancer incidence and mortality as well as specific cancer risk factors including smoking, alcohol consumption, overweight or obesity, HBV (“hepatitis B”), HPV (“papillomavirus infections” or “Papillomaviridae”), EBV (“Epstein-Barr virus infections”), and HHV8 (“herpesvirus 8, human”).

2.2. Eligibility Criteria

The following inclusion criteria were applied: (i)Involving individuals aged 18 years and above(ii)Conducted between 2010 and 2023(iii)Using quantitative study designs(iv)Published in English language only

The following exclusion criteria were applied: (i)Involving children; or(ii)Published before 2010(iii)Using qualitative methodology(iv)Published in language other than English

2.3. Data Extraction

Data were extracted and collated in Microsoft Excel. Quantitative studies including cross-sectional, retrospective, and prospective cohort studies were identified. While cross-sectional data cannot estimate cancer incidence and mortality rates, the studies can be useful in estimating prevalence and identifying trends because of the ability to collect data across different groups at a given point in time [38, 39]. The extracted data from each article included the authors’ names, year of publication, the date/period of the study, and the study design. Other information extracted were the setting/country(ies) where the study was conducted, the study population/sample, sex/gender studied and key findings presented as proportions/incidence/mortality rates of cancers, ADCs and NADCs, and the measurement of various risk factors.

2.4. Data Analysis

Articles were tabulated and summarized by any cancer, ADCs (KS, NHL, and cervical cancer) and NADCs. Where applicable, NADCs were categorized as virus-related and nonvirus-related and compared among the PLHIV and those without HIV. Burden trends for individual ADCs and NADCs were assessed to identify increases or decreases in incidence over different time periods from pre-ART through late cART era. Trends between individual LMICs and HICs were further summarized and compared. Risk factors for cancer incidence and mortality were also summarized.

3. Results

A total of 1886 articles were identified from the three databases. Applying the criteria, 1635 studies were excluded (Figure 1). Each of the remaining 251 abstracts was screened for eligibility, and 51 were included for full text article review. Out of these, 36 studies were deemed eligible for inclusion in the analysis. The characteristics of the included studies are outlined in Table 1. Majority of the studies, 22 (61%) used a retrospective cohort study design and seven (19%) were cross-sectional. More than 50% () of the studies were carried out in HICs, six (17%) were done in the LMICs, and four (11%) in low-income countries (LICs), specifically in sub-Saharan Africa (SSA). Out of the 28 studies that specified gender, 22 (79%) had a sample that constituted more males than females, 4 (14%) had more females than males, and all of them were in SSA, and for each of the remaining two studies, one focused on males and the other on females only. Out of the 36 studies, 31 assessed the incidence of both ADCs and NADCs, and 15 of these reported on mortality. Five studies focused on NADCs only.

The leading individual ADCs were NHL and KS reported by 11 studies each, and majority of these studies were from upper-middle and high-income countries. Cervical cancer was reported by seven studies as the most common ADCs, and five of these studies were done in SSA. The leading NADC reported by nine studies was lung cancer followed by HL and breast cancers. Similarly, all the five out of seven studies that reported breast cancer as the commonest were from LMICs based in SSA.

Table 2 shows 31 of the 36 studies that compared the incidence and mortality of ADCs and NADCs. A total of 17 studies found higher incidence of NADCs when contrasted with ADCs, and 12 of these were conducted in HICs. Twelve studies reported higher incidence of ADCs than NADCs, and of these eight were from LMIC and UMICs. Only two studies showed similar proportions of both ADCs and NADCs. Nine studies compared cancer incidence between the PLHIV and the HIV negative or general population, and of these, six studies from both HICs and LMICs countries reported a higher incidence of ADCs in PLHIV compared to their HIV-negative counterparts. Similarly, four studies showed an increase of NADCs in PLHIV versus those HIV negative. Only two studies observed an increased rate of NADCs including nonvirus-related NADCs in the HIV-negative individuals, while one study showed similar rates of NADCs in both groups.

A total of 11 studies compared cancer-related mortality between ADCs and NADCs, and of these, seven studies from HIC and UMICs reported more NADC-related deaths than ADC-related deaths, three studies reported more ADC than NADC-related deaths, while only one study revealed similar proportions of ADC and NADC-related deaths. When compared to the general population, only two studies, one from a HIC and the other from a LIC, revealed higher rates of overall cancer mortality among PLHIV.

Four studies compared the incidence of virus and nonvirus-related NADCs among PLHIV. Of these, only one study from Italy found an increase in virus-related NADCS versus nonvirus ones, while the remaining three (all of them done in USA) showed that nonvirus-related NADCs were in the increase when compared with virus-related NADCs. Mortality was investigated by the Italian study only, and the results showed more nonvirus NADC-related deaths versus virus-related NADC deaths.

A total of seven studies (6 HICs and 1 UMIC) documented a decline in the incidence ADCs and NADCs during ART program expansion. In contrast, three studies (2 HICs and 1 UMIC) reported an increase in NADC rates while four others showed that the incidence of NADCs remained stable over the ART expansion period. Decreasing overall cancer rates were noted by only two studies from HICs.

Risk factors associated with cancer incidence and mortality are summarized in Table 3. The most common factor identified as a risk for the occurrence of any cancer was advancing age reported by three studies, followed by low CD4 cell/μl documented by two studies. Other important risk factors for cancer among PLHIV were longer duration of HIV infection, coexistence of clinical AIDS, tobacco use, male gender, and not being on ART, each noted by one study. Five studies also identified advancing age as a significant risk factor for non-AIDS-defining cancers (NADCs), aligning with the aforementioned factors. Only three studies evaluated the risks linked to ADCs with the main risk factor being low CD4 cell/μl at ART initiation. Other risks for ADCs reported by one study each were lack of viral load suppression, presence of opportunistic infections, and previous cancer history.

Factors associated with increased risk of any cancer-related mortality among PLHIV were identified by one study as poor immune status, lack of cancer treatment, and cancer staging III and IV. Other predictors of cancer mortality were high viral copies/ml reported by two studies, increasing age documented by two studies, longer duration with HIV noted by one study, and being not on ART also reported by one study. Specifically, deaths related to NADCs were linked to advancing age, CD4 cell/μl, and AIDS comorbidity documented by two studies each. Lower CD4 cell/μl was further identified by two studies as a high risk for ADC-related mortality.

4. Discussion

This narrative review provides an overview of the trends of ADCs and NADCs in PLHIV compared to the general population. In more than half of the studies examined, elevated numbers of NADCs were observed in PLHIV when compared to ADCs. The review also revealed a declining trend in ADCs [50, 58, 61, 65, 69], while NADCs showed an increasing [57, 58, 65] or stable pattern [32, 50, 61, 69] from the pre-ART to late ART period. These findings align with previous studies indicating that the introduction and expansion of cART over the past two decades has significantly improved immune function and life expectancy among PLHIV, leading to a decrease in ADC incidence and an increase in NADCs due to prolonged survival [42, 53, 73]. This pattern was further confirmed by four studies [58, 67, 69, 71] in our review that compared virus-related NADCs to nonvirus-related NADCs in PLHIV, and three of these studies all from USA found that the latter were on the rise. As with ADCs, virus-related NADCs are linked to similar infectious agents such as HPV and the declines in their incidence could also be attributed to the effectiveness of ART. However, there is a need for research to understand the risk and trends of this class of NADCs particularly in LMICs. None of the LMIC studies in our review investigated NADCs as virus or nonvirus related.

Despite decreasing rates of ADCs, this review found that when compared with the HIV-negative individuals, all relevant studies documented higher ADCs rates among PLHIV. The most prevalent ADCs were NHL and KS in the upper-middle and high-income countries and cervical cancer in LMICs. Regarding NADCs, a similar trend was seen where seven of the nine studies reported increased rates of NADCs in PLHIV with lung cancer taking the lead. This observation is supported by data from SSA countries that have demonstrated that cancer associated with HIV/AIDS is a prevalent problem despite the roll out of cART where PLHIV were found to be at higher risk of ADCs than the general population [6–11, 74]. Therefore, with the rates of ADCs and NADCs elevated in PLHIV, it is paramount that healthcare providers prioritize regular screening and early detection, promote health education and health lifestyle behaviors, and offer comprehensive management for ADCs and NADCs in this population, while sustaining access to and adherence to cART.

Our analyses by country-income status showed that the overall incidence of ADCs in PLHIV were higher in LMICs while NADCs were higher in HICs. The increased rates of NADCs in HICs are consistent with evidence from several studies that have noted that while the scale-up of cART in HICs has led to significant declines in ADCs, the incidence of NADCs has been increasing [31, 32, 36, 75]. On the other hand, the trend of higher ADCs in LMICs has been attributed to various reasons including a substantial number of HIV-infected people who are not aware of their HIV status, with some initiating ART late with low CD4 cell cell/μl and advanced immunosuppression while others are not on ART despite being eligible for the treatment [1, 76]. In our review, cervical cancer, an ADC, was the most prevalent cancer in LMICs with all the studies from SSA reporting it as the leading cancer cause.

The majority of studies that reported on mortality in this review showed that when compared with ADCs, NADCs were responsible for more cancer-related deaths in PLHIV with lung cancer being the leading cause. The incidence of lung cancer has been found to be substantially higher in PLHIV, partly due to aging and tobacco use and also because of immunosuppression and inflammatory processes associated with chronic HIV infection [60, 77, 78]. Another study in this review found that women with cancer and HIV-infection with lower CD4 cell counts had shorter survival when compared with their HIV-negative counterparts [49]. The high cancer-related mortality among PLHIV is also linked to late presentation with advanced disease [79] with six studies [40, 41, 55, 60, 68, 71] in our review reporting that the majority of PLHIV with cancer presented with stages III and IV or advanced disease.

The most common risk factors associated with the occurrence of any cancer, NADCs, and the related cancer mortality were advancing age [46, 52, 54, 57, 59, 61, 63, 67, 72] and longer duration with HIV infection [11, 52, 54, 56, 64, 72]. A US-based study conducted over a 15-year period has shown that increases in the rates of NADCs were mainly driven by growth and aging of PLHIV [29]. Our review further revealed that lower CD4 cell cell/μl [32, 47, 59, 67, 69, 70, 72] was also noted as a prevalent risk for ADCs, NADCs, and associated mortality highlighting the role that immunosuppression plays in predisposing PLHIV to cancer. Another important risk factor for cancer incidence and mortality observed in this review was male gender. Though reported by only three studies [45, 59], this finding is not surprising as we noted that two-thirds of all the 36 included studies had larger samples of males coinfected with cancer and HIV than females. There is evidence suggesting that men are more prone to developing cancer when compared with women, and while the reasons for this are multipronged, the primary difference is linked to the genetic or molecular level regulation including sex hormones like estrogen [80, 81].

4.1. Implications for Practice

This study presents a need for policy makers in public health to take note of the increasing trends of NADCs in the light of PLHIV living longer on cART. This will facilitate planning and decision making aimed at developing targeted effective interventions that can prevent or lead to early diagnosis and treatment of these cancers. The findings also suggest that the high rates of ADCs particularly in LMICs where some PLHIV are not on ART requires a swift response by each country not only to adopt the WHO “test and treat all policy” but to also implement it and evaluate its effectiveness. The policy was recommended in 2016 for people infected with HIV to start ART on the same day of diagnosis, and by June 2019, 93% of all the LMICs had adopted it while only 84% had started to put it in practice [37]. Evidence from this review further points to a need to consider male gender as an important predictor of cancer, and strategies of promoting early access to cancer care services by men may need to be considered. Finally, our study findings showed that there were limited data on ADCs and NADCs among PLHIV in LMICs especially SSA suggesting the need for future research in these settings.

4.2. Limitations

Our narrative review has some limitations. First, two-thirds of the studies used a retrospective design where the accuracy of data cannot be verified due to the use of records that were not designed for the study. Secondly, various methodologies in this review bring in differences in designs in the study settings, population, procedures, and data quality, making it difficult to make accurate comparisons. Thirdly, there was paucity of studies from LMICs, especially in SSA, thus making it difficult to generalize the findings to all the regions. However, notwithstanding these limitations, this review presents evidence that shows the increasing cancer trends in PLHIV, especially the NADCs, and supports the need for effective cancer screening strategies to reduce the cancer burden through early detection and appropriate treatment.

5. Conclusion

Chronic HIV infection combined with advancing age in PLHIV who are on cART are major contributors to the increasing cancer trends, particularly the incidence of NADCs, and the related mortality in this population. Our study provides evidence that when compared with the general population, PLHIV have an increased risk of both ADCs and NADCs with specific cancers such as lung, NHL, KS, cervical, and breast cancers being the most common. These findings stress the importance of screening for cancers among PLHIV, and the need for further research, to better understand the pathogenesis and predictors of both ADCs and NADCs and the increasing incidence of NADCs both virus and nonvirus-related NADCs especially in LMICs, to guide the development of targeted preventive and therapeutic interventions.

Data Availability

The data reported and supporting this paper was sourced from the existing literature and is therefore available through the detailed reference list.

Disclosure

This study is done and submitted in fulfillment of a PhD study at the University of KwaZulu-Natal, which is also the sponsor of the PhD.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Acknowledgments

Open Access funding is enabled and organized by SANLiC Gold.

References

World Health Organization, “Health topics: HIV/AIDS 2022,” https://www.who.int/news-room/fact-sheets/detail/hiv-aids.
View at: Google Scholar
M. S. Shiels and E. A. Engels, “Evolving epidemiology of HIV-associated malignancies,” Current Opinion in HIV and AIDS, vol. 12, no. 1, pp. 6–11, 2017.
View at: Publisher Site | Google Scholar
R. Dubrow, M. J. Silverberg, L. S. Park, K. Crothers, and A. C. Justice, “HIV infection, aging, and immune function,” Current Opinion in Oncology, vol. 24, no. 5, pp. 506–516, 2012.
View at: Publisher Site | Google Scholar
World Health Organization, “Cancer: fact sheets 2022,” https://www.who.int/news-room/fact-sheets/detail/cancer.
View at: Google Scholar
International Agency for Research on Cancer Globocan, “Cancer today: population fact sheets: Regions,” 2020, https://gco.iarc.fr/today/fact-sheets-populations.
View at: Google Scholar
S. Dryden-Peterson, H. Medhin, M. Kebabonye-Pusoentsi et al., “Cancer incidence following expansion of HIV treatment in Botswana,” PLOS One, vol. 10, no. 8, article e0135602, 2015.
View at: Publisher Site | Google Scholar
S. N. Elmore, E. S. Bigger, M. K. Kayembe et al., “Demographic characteristics and preliminary outcomes in a cohort of HIV-positive patients with Kaposi’s sarcoma in high ART coverage setting: a report from Botswana,” Journal of Global Oncology, vol. 2, no. 3, 2016.
View at: Publisher Site | Google Scholar
M. G. Miligan, E. Bigger, J. Abramson et al., “Impact of HIV infection on the clinical presentation and survival of non-Hodgkin lymphoma: a prospective observational study from Botswana,” Journal of Global Oncology, vol. 4, no. 4, pp. 1–11, 2018.
View at: Publisher Site | Google Scholar
S. Dryden-Peterson, M. Bvochora-Nsingo, G. Suneja et al., “HIV infection and survival among women with cervical cancer,” Journal of Clinical Oncology, vol. 34, no. 31, pp. 3749–3757, 2016.
View at: Publisher Site | Google Scholar
E. Rogena, K. Simbiri, G. De Falco, L. Leoncini, L. Ayers, and J. Nyagol, “A review of the pattern of AIDS defining, HIV associated neoplasms and premalignant lesions diagnosed from 2001-2011 at Kenyatta National Hospital, Kenya,” BMC, Infectious Agents and Cancer, vol. 10, no. 28, 2015.
View at: Google Scholar
R. Ignacio, M. Ghadrshenas, D. Low, J. Orem, C. Casper, and W. Phipps, “HIV status and associated clinical characteristics among adult patients with cancer at the Uganda Cancer Institute,” Journal of Global Oncology, vol. 4, no. 4, pp. 1–10, 2018.
View at: Publisher Site | Google Scholar
R. Mitsuyasu, “Non–AIDS-defining cancers,” Topics in Antiviral Medicine, vol. 22, no. 3, pp. 660–665, 2014.
View at: Google Scholar
P. Rubinsteina, D. Aboulafiac, and A. Zlozab, “Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges,” AIDS, vol. 28, no. 4, pp. 453–465, 2014.
View at: Publisher Site | Google Scholar
R. Hernández-Ramírez, M. Shiels, R. Dubrow, and E. Engels, “Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study,” Lancet HIV, vol. 4, no. 11, pp. e495–e504, 2017.
View at: Publisher Site | Google Scholar
J. Bohlius, F. Valeri, M. Maskew et al., “Kaposi’s sarcoma in HIV-infected patients in South Africa: multicohort study in the antiretroviral therapy era,” International Journal of Cancer, vol. 135, no. 11, pp. 2644–2652, 2014.
View at: Publisher Site | Google Scholar
J. Livingston, “Cancer in the shadow of the AIDS epidemic in Southern Africa,” The Oncologist, vol. 18, no. 7, pp. 783–786, 2013.
View at: Publisher Site | Google Scholar
N. B. Bradie and D. TLy, “Kaposi sarcoma,” 2023, https://www.ncbi.nlm.nih.gov/books/NBK534839/.
View at: Google Scholar
E. M. Burd, “Human papillomavirus and cervical cancer,” Clinical Microbiology Reviews, vol. 16, no. 1, pp. 1–17, 2003.
View at: Publisher Site | Google Scholar
S. Sapkota and H. Shaikh, “Non-hodgkin lymphoma,” 2023, https://www.ncbi.nlm.nih.gov/books/NBK559328/.
View at: Google Scholar
S. N. Akarolo-Anthony, L. D. Maso, F. Igbinoba, S. M. Mbulaiteye, and C. A. Adebamowo, “Cancer burden among HIV-positive persons in Nigeria: preliminary findings from the Nigerian AIDS-cancer match study,” Infectious Agents and Cancer, vol. 9, no. 1, p. 1, 2014.
View at: Publisher Site | Google Scholar
K. Chaabna, M. Boniol, H. de Vuyst, P. Vanhems, M. A. D. Vitoria, and M. P. Curado, “Geographical patterns of Kaposi's sarcoma, nonHodgkin lymphomas, and cervical cancer associated with HIV infection in five African populations,” European Journal of Cancer Prevention, vol. 21, no. 1, pp. 1–9, 2012.
View at: Publisher Site | Google Scholar
S. V. Godbole, K. Nandy, M. Gauniyal et al., “HIV and cancer registry linkage identifies a substantial burden of cancers in persons with HIV in India,” Medicine, vol. 95, no. 37, article e4850, 2016.
View at: Publisher Site | Google Scholar
J. Martin, M. Wenger, N. Busakhala et al., “Prospective evaluation of the impact of potent antiretroviral therapy on the incidence of Kaposi’s sarcoma in East Africa: findings from the International Epidemiologic Databases to Evaluate AIDS (IeDEA) consortium,” BMC Infectious Agents and Cancer, vol. 7, Supplement 1, 2012.
View at: Publisher Site | Google Scholar
H. A. Robbins, M. S. Shiels, R. M. Pfeiffer, and E. A. Engels, “Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States,” AIDS, vol. 28, no. 6, pp. 881–890, 2014.
View at: Publisher Site | Google Scholar
P. Patel, C. Armon, J. S. Chmiel et al., “Factors associated with cancer incidence and with all-cause mortality after cancer diagnosis among human immunodeficiency virus-infected persons during the combination antiretroviral therapy era,” Open Forum Infectious Diseases, vol. 1, no. 1, article ofu012, 2014.
View at: Google Scholar
L. S. Park, R. U. Hernández-Ramírez, M. J. Silverberg, K. Crothers, and R. Dubrow, “Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS,” AIDS, vol. 30, no. 2, pp. 273–291, 2016.
View at: Publisher Site | Google Scholar
M. Hleyhel, A. M. Bouvier, A. Belot et al., “Risk of non-AIDS-defining cancers among HIV-1-infected individuals in France between 1997 and 2009: results from a French cohort,” AIDS, vol. 28, no. 14, pp. 2109–2118, 2014.
View at: Publisher Site | Google Scholar
P. Goncalves, J. Montezuma-Rusca, R. Yarchoan, and T. Uldrick, “Cancer prevention in HIV-infected populations,” Seminars in Oncology, vol. 43, no. 1, pp. 173–188, 2016.
View at: Publisher Site | Google Scholar
M. Shiels, R. Pfeiffer, M. Gail et al., “Cancer burden in the HIV-infected population in the United States,” Journal of the National Cancer Institute, vol. 103, no. 9, pp. 753–762, 2011.
View at: Publisher Site | Google Scholar
M. Silverberg, W. Leyden, E. Warton, C. J. Quesenberry, E. Engels, and M. Asgari, “HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer,” Journal of the National Cancer Institute, vol. 105, no. 5, pp. 350–360, 2013.
View at: Publisher Site | Google Scholar
C. G. Chiu, D. Smith, K. A. Salters et al., “Overview of cancer incidence and mortality among people living with HIV/AIDS in British Columbia, Canada: implications for HAART use and NADM development,” BMC Cancer, vol. 17, no. 1, p. 270, 2017.
View at: Publisher Site | Google Scholar
D. Gotti, E. Raffetti, L. Albini et al., “Survival in HIV-infected patients after a cancer diagnosis in the cART era: results of an Italian multicenter study,” PLoS One, vol. 9, no. 4, article e94768, 2014.
View at: Publisher Site | Google Scholar
W. Zhu, Y. Mao, H. Tang et al., “Spectrum of malignancies among the population of adults living with HIV infection in China: a nationwide follow-up study, 2008–2011,” PLoS One, vol. 14, no. 7, article e0219766, 2019.
View at: Publisher Site | Google Scholar
E. Y. Chiao, A. Coghill, D. Kizub et al., “The effect of non-AIDS-defining cancers on people living with HIV,” Lancet Oncology, vol. 22, no. 6, pp. E240–e253, 2021.
View at: Publisher Site | Google Scholar
T. Dhokotera, J. Bohlius, A. Spoerri et al., “The burden of cancers associated with HIV in the South African public health sector, 2004-2014: a record linkage study,” BMC, Infectious Agents and Cancer, vol. 14, no. 12, p. 12, 2019.
View at: Publisher Site | Google Scholar
M. Vogel, O. Friedrich, G. Luchters et al., “Cancer risk in HiV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence,” European Journal of Medical Research, vol. 16, no. 3, pp. 101–107, 2011.
View at: Publisher Site | Google Scholar
World Health Organization, “WHO HIV policy adoption and implementation status in countries,” 2019, file:///C:/Users/mathomaa/Downloads/WHO-CDS-HIV-19.20-eng.pdf.
View at: Google Scholar
B. Linden, R. Boyes, and H. Stuart, “Cross-sectional trend analysis of the NCHA II survey data on Canadian post-secondary student mental health and wellbeing from 2013 to 2019,” BMC Public Health, vol. 21, no. 1, 2021.
View at: Google Scholar
M. S. Setia, “Methodology series module 3: cross-sectional studies,” Indian Journal Dermatology, vol. 61, no. 3, pp. 261–264, 2016.
View at: Publisher Site | Google Scholar
G. Kauma, H. Ddungu, I. Ssewanyana et al., “Virologic nonsuppression among patients with HIV newly diagnosed with cancer at Uganda Cancer Institute: cross-sectional study,” JCO Global Oncology, vol. 9, no. 9, 2023.
View at: Publisher Site | Google Scholar
D. Muturi, S. N. Mwanzi, F. M. Riunga, J. Shah, and R. Shah, “HIV prevalence and characteristics among patients with AIDS-defining and non–AIDS-defining cancers in a tertiary hospital in Kenya,” JCO Global Oncology, vol. 9, no. 9, 2023.
View at: Publisher Site | Google Scholar
S. Arora, A. Mahesh, N. K. Mahesh, and N. Verma, “Spectrum of malignancies among human immunodeficiency virus-infected patients at a tertiary level human immunodeficiency virus-anti-retroviral therapy center in a North Indian Hospital,” Indian Journal of Sexually Transmitted Diseases and AIDS, vol. 42, no. 2, pp. 118–124, 2021.
View at: Publisher Site | Google Scholar
M. J. Horner, M. S. Shiels, R. M. Pfeiffer, and E. A. Engels, “Deaths Attributable to Cancer in the US Human Immunodeficiency Virus Population During 2001-2015,” Clinical Infectious Diseases, vol. 72, no. 9, pp. e224–ee31, 2021.
View at: Publisher Site | Google Scholar
L. M. Mendoza-Mori, J. B. Valenzuela-Medina, E. Gotuzzo, F. A. Mejía-Cordero, and E. V. González-Lagos, “Cancer in people living with HIV-AIDS at a referral hospital in Lima, Peru,” Revista Peruana De Medicina Experimental Y Salud Publica, vol. 38, no. 2, pp. 278–283, 2021.
View at: Publisher Site | Google Scholar
M. Patel, J. L. Waller, S. L. Baer et al., “Cancer incidence and risk factors in dialysis patients with human immunodeficiency virus: a cohort study,” Clinical Kidney Journal, vol. 14, no. 2, pp. 624–630, 2021.
View at: Publisher Site | Google Scholar
A. B. Spence, M. E. Levy, A. Monroe et al., “Cancer incidence and cancer screening practices among a cohort of persons receiving HIV Care in Washington, DC,” Journal of Community Health, vol. 46, no. 1, pp. 75–85, 2021.
View at: Publisher Site | Google Scholar
F. Wang, P. Xiang, H. Zhao et al., “A retrospective study of distribution of HIV associated malignancies among inpatients from 2007 to 2020 in China,” Scientific Reports, vol. 11, no. 1, article 24353, 2021.
View at: Publisher Site | Google Scholar
O. Altuntas Aydin, A. Gunduz, F. Sargin et al., “Prevalence and mortality of cancer among people living with HIV and AIDS patients: a large cohort study in Turkey,” Eastern Mediterranean Health Journal, vol. 26, no. 3, pp. 276–282, 2020.
View at: Publisher Site | Google Scholar
K. L. Calkins, G. Chander, C. E. Joshu et al., “Short communication: differences in 5-year survival after cancer diagnosis between HIV clinic enrollees and the general U.S. population,” AIDS Research and Human Retroviruses, vol. 36, no. 2, pp. 116–118, 2020.
View at: Publisher Site | Google Scholar
V. Gheorghiță, I. F. Conea, A. M. C. Radu et al., “Epidemiological trends and therapeutic challenges of malignancies in adult HIV-1-infected patients receiving combination antiretroviral therapy in a tertiary hospital from Romania: an observational retrospective study,” Journal of Infection and Public Health, vol. 12, no. 2, pp. 182–189, 2019.
View at: Publisher Site | Google Scholar
S. Sinha, A. Agarwal, K. Gupta et al., “Prevalence of HIV in Patients with Malignancy and of Malignancy in HIV Patients in a Tertiary Care Center from North India,” Current HIV Research, vol. 16, no. 4, pp. 315–320, 2019.
View at: Publisher Site | Google Scholar
O. Billa, M. Chalouni, D. Salmon et al., “Factors associated with non-AIDS-defining cancers and non-HCV-liver related cancers in HIV/HCV-coinfected patients-ANRS-CO13 HEPAVIH cohort,” PLoS One, vol. 13, no. 12, article e0208657, 2018.
View at: Publisher Site | Google Scholar
P. Cornejo-Juarez, D. Cavildo-Jeronimo, and P. Volkow-Fernandez, “Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico,” AIDS Research and Therapy, vol. 15, no. 1, p. 16, 2018.
View at: Publisher Site | Google Scholar
V. I. Fink, C. A. Jenkins, J. L. Castilho et al., “Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America,” Infectious Agents and Cancer, vol. 13, no. 1, p. 16, 2018.
View at: Publisher Site | Google Scholar
S. Grover, F. Desir, Y. Jing et al., “Reduced cancer survival among adults with HIV and AIDS-defining illnesses despite no difference in cancer stage at diagnosis,” Journal of Acquired Immune Deficiency Syndromes, vol. 79, no. 4, pp. 421–429, 2018.
View at: Publisher Site | Google Scholar
M. A. Kowalkowski, R. S. Day, X. L. Du, W. Chan, and E. Y. Chiao, “Cumulative HIV viremia and non–AIDS-defining malignancies among a sample of HIV-infected male veterans,” Journal of Acquired Immune Deficiency Syndromes, vol. 67, no. 2, pp. 204–211, 2014.
View at: Publisher Site | Google Scholar
N. Nagata, T. Nishijima, R. Niikura et al., “Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study,” BMC Cancer, vol. 18, no. 1, p. 1066, 2018.
View at: Publisher Site | Google Scholar
L. S. Park, J. P. Tate, K. Sigel et al., “Association of viral suppression with lower AIDS-defining and non–AIDS-defining cancer incidence in HIV-infected veterans,” Annals of Internal Medicine, vol. 169, no. 2, pp. 87–96, 2018.
View at: Publisher Site | Google Scholar
E. A. Engels, E. L. Yanik, W. Wheeler et al., “Cancer-attributable mortality among people with treated human immunodeficiency virus infection in North America,” Clinical Infectious Disease, vol. 65, no. 4, pp. 636–643, 2017.
View at: Publisher Site | Google Scholar
J. A. Campbell, A. S. Soliman, C. Kahesa, S. D. Harlow, and D. Msemo, “Changing patterns of lung, liver, and head and neck non-AIDS-defining cancers relative to HIV status in Tanzania between 2002-2014,” Infectious Agents and Cancer, vol. 11, no. 1, p. 58, 2016.
View at: Publisher Site | Google Scholar
A. M. Mayor, E. J. Santiago-Rodriguez, E. Rios-Olivares, G. Tortolero-Luna, and R. F. Hunter-Mellado, “Malignancies trends in a Hispanic cohort of HIV persons in Puerto Rico before and after cART,” International Journal of Cancer Research, vol. 12, no. 2, pp. 92–100, 2016.
View at: Publisher Site | Google Scholar
K. Salters, A. Cescon, W. Zhang et al., “Cancer incidence among HIV-positive women in British Columbia, Canada: Heightened risk of virus-related malignancies,” HIV Medicine, vol. 17, no. 3, pp. 188–195, 2016.
View at: Publisher Site | Google Scholar
J. Yang, S. Su, H. Zhao et al., “Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China,” BMC Infectious Diseases, vol. 16, no. 1, p. 82, 2016.
View at: Publisher Site | Google Scholar
A. Jaquet, M. Odutola, D. K. Ekouevi et al., “Cancer and HIV infection in referral hospitals from four West African countries,” Cancer Epidemiology, vol. 39, no. 6, pp. 1060–1065, 2015.
View at: Publisher Site | Google Scholar
E. Raffetti, L. Albini, D. Gotti et al., “Cancer incidence and mortality for all causes in HIV-infected patients over a quarter century: a multicentre cohort studY,” BMC Public Health, vol. 15, no. 1, p. 235, 2015.
View at: Publisher Site | Google Scholar
M. J. Silverberg, B. Lau, C. J. Achenbach et al., “Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study,” Annals of Internal Medicine, vol. 163, no. 7, pp. 507–518, 2015.
View at: Publisher Site | Google Scholar
A. Calabresi, A. Ferraresi, A. Festa et al., “Incidence of AIDS-defining cancers and virus-related and non-virus-related non-AIDS-defining cancers among HIV-infected patients compared with the general population in a large health district of northern Italy, 1999-2009,” HIV Medicine, vol. 14, no. 8, pp. 481–490, 2013.
View at: Publisher Site | Google Scholar
A. E. Coghill, P. A. Newcomb, M. M. Madeleine et al., “Contribution of HIV infection to mortality among cancer patients in Uganda,” AIDS, vol. 27, no. 18, pp. 2933–2942, 2013.
View at: Publisher Site | Google Scholar
E. L. Yanik, S. Napravnik, S. R. Cole et al., “Incidence and timing of cancer in HIV-infected individuals following initiation of combination antiretroviral therapy,” Clinical Infectious Diseases, vol. 57, no. 5, pp. 756–764, 2013.
View at: Publisher Site | Google Scholar
L. F. D. S. Pinto Neto, M. D. C. Milanez, J. E. Golub, and A. E. B. Miranda, “Malignancies in HIV/AIDS patients attending an outpatient clinic in Vitória, state of Espírito Santo, Brazil,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 45, no. 6, pp. 687–690, 2012.
View at: Publisher Site | Google Scholar
C. J. Achenbach, S. R. Cole, M. M. Kitahata et al., “Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapy,” AIDS, vol. 25, no. 5, pp. 691–700, 2011.
View at: Publisher Site | Google Scholar
N. Dauby, S. De Wit, M. Delforge, V. C. Necsoi, and N. Clumeck, “Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study,” Journal of the International AIDS Society, vol. 14, no. 1, p. 16, 2011.
View at: Publisher Site | Google Scholar
N. A. Hessol, D. Ma, S. Scheer, L. C. Hsu, and S. K. Schwarcz, “Changing temporal trends in non-AIDS cancer mortality among people diagnosed with AIDS: San Francisco, California, 1996–2013,” Cancer Epidemiology, vol. 52, pp. 20–27, 2018.
View at: Publisher Site | Google Scholar
International Agency for Research on Cancer-Globocan, “Botswana cancer,” 2018, https://gco.iarc.fr/today/fact-sheets-cancers.
View at: Google Scholar
A. Bearz, E. Vaccher, F. Martellotta et al., “Lung cancer in HIV positive patients: the GICAT experience,” European Review for Medical and Pharmacological Sciences, vol. 18, no. 8, pp. 500–508, 2014.
View at: Google Scholar
D. Avila, K. Althoff, C. Mugglin et al., “Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries,” Journal of Acquired Immune Deficiency Syndrome, vol. 65, no. 1, pp. e8–e16, 2014.
View at: Publisher Site | Google Scholar
J. Moltó, T. Moran, G. Sirera, and B. Clotet, “Lung cancer in HIV-infected patients in the combination antiretroviral treatment era,” Translational Lung Cancer Research, vol. 4, no. 6, pp. 678–688, 2015.
View at: Publisher Site | Google Scholar
K. Sigel, A. Makinson, and J. Thaler, “Lung cancer in persons with HIV,” Current Opinion in HIV and AIDS, vol. 12, no. 1, pp. 31–38, 2017.
View at: Publisher Site | Google Scholar
World Health Organization, “Health Topics: Cancer,” 2019, https://www.who.int/health-topics/cancer#tab=tab_1.
View at: Google Scholar
H.-I. Kim, H. Lim, and A. Moon, “Sex differences in cancer: epidemiology, genetics and therapy,” Biomolecules & Therapeutics, vol. 26, no. 4, pp. 335–342, 2018.
View at: Publisher Site | Google Scholar
I. Peate, “Men and cancer: the gender dimension,” British Journal of Nursing, vol. 20, no. 6, pp. 340–343, 2011, 2-3.
View at: Publisher Site | Google Scholar

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